The role of circular RNAs in pulmonary hypertension
Abstract
Circular RNAs (circRNAs) are endogenous, covalently circularised, non-protein-coding RNAs generated from back-splicing. Most circRNAs are very stable, highly conserved, and expressed in a tissue-, cell- and developmental stage-specific manner. circRNAs play a significant role in various biological processes, such as regulation of gene expression and protein translationviasponging of microRNAs and binding with RNA-binding proteins. circRNAs have become a topic of great interest in research due to their close link with the development of various diseases. Their high stability, conservation and abundance in body fluids make them promising biomarkers for many diseases. A growing body of evidence suggests that aberrant expression of circRNAs and their targets plays a crucial role in pulmonary vascular remodelling and pulmonary arterial hypertension (group 1) as well as other forms (groups 3 and 4) of pulmonary hypertension (PH). Here we discuss the roles and molecular mechanisms of circRNAs in the pathogenesis of pulmonary vascular remodelling and PH. We also highlight the therapeutic and biomarker potential of circRNAs in PH.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 09, 2022
- Source ID
- 10.1183/13993003.00012-2022
Entities
People
- Chun-kan Chen
- Edda Spiekerkoetter
- Kamal Dua
- Katharina Schimmel
- Lan Zhao
- Mark Nicolls
- Md Khadem Ali
Organizations
- National Institutes of Health
- United States Department of Defense