Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized
Abstract
Human mammary epithelial cells (HMEC) overcome two well-characterized genetic and epigenetic barriers as they progress from primary cells to fully immortalized cell lines in vitro. Finite lifespan HMEC overcome an Rb-mediated stress-associated senescence barrier (stasis), and a stringent, telomere-length dependent, barrier (agonescence or crisis, depending on p53 status). HMEC that have overcome the second senescence barrier are immortalized.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 18, 2007
- Source ID
- 10.1186/1476-4598-6-7
Entities
People
- Chris Tunkey
- James C. Garbe
- Jee Hyung Lee
- Jian-liang Li
- Jing Pan
- Katie Saraf
- Martha R Stampfer
- Maryann Z Whitley
- Scott A Jelinsky
- Steven A Haney
- Yizheng Li