Computational analysis of pathogen-borne metallo β-lactamases reveals discriminating structural features between B1 types
Abstract
Genes conferring antibiotic resistance to groups of bacterial pathogens are cause for considerable concern, as many once-reliable antibiotics continue to see a reduction in efficacy. The recent discovery of the metallo β-lactamase blaNDM-1 gene, which appears to grant antibiotic resistance to a variety of Enterobacteriaceae via a mobile plasmid, is one example of this distressing trend. The following work describes a computational analysis of pathogen-borne MBLs that focuses on the structural aspects of characterized proteins.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 14, 2012
- Source ID
- 10.1186/1756-0500-5-96
Entities
People
- Adam Zemła
- Carol L. Ecale Zhou
- Eithon Cadag
- Elizabeth Vitalis
- Kristin P Lennox