Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series
Abstract
Mechanically ventilated patients with COVID-19 have a mortality of 24–53%, in part due to distal mucopurulent secretions interfering with ventilation. DNA from neutrophil extracellular traps (NETs) contribute to the viscosity of mucopurulent secretions and NETs are found in the serum of COVID-19 patients. Dornase alfa is recombinant human DNase 1 and is used to digest DNA in mucoid sputum. Here, we report a single-center case series where dornase alfa was co-administered with albuterol through an in-line nebulizer system.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 29, 2020
- Source ID
- 10.1186/s10020-020-00215-w
Entities
People
- Alice S Chau
- Andrew G. Weber
- Betsy J Barnes
- Mikala Egeblad
- Tobias Janowitz
Organizations
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- United States Department of Defense