Identification of adipose tissue transcriptomic memory of anorexia nervosa
Abstract
Anorexia nervosa (AN) is a complex debilitating disease characterized by intense fear of weight gain and excessive exercise. It is the deadliest of any psychiatric disorder with a high rate of recidivism, yet its pathophysiology is unclear. The Activity-Based Anorexia (ABA) paradigm is a widely accepted mouse model of AN that recapitulates hypophagia and hyperactivity despite reduced body weight, however, not the chronicity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 15, 2023
- Source ID
- 10.1186/s10020-023-00705-7
Entities
People
- Chanond A. Nasamran
- Daisy R. Chilin-fuentes
- Olivia Osborn
- Rizaldy C Zapata
- Stephanie C. Dulawa
Organizations
- Larry L. Hillblom Foundation
- National Center for Advancing Translational Sciences
- United States Department of Defense