DBSecSys 2.0: a database of Burkholderia mallei and Burkholderia pseudomallei secretion systems
Abstract
Burkholderia mallei and B. pseudomallei are the causative agents of glanders and melioidosis, respectively, diseases with high morbidity and mortality rates. B. mallei and B. pseudomallei are closely related genetically; B. mallei evolved from an ancestral strain of B. pseudomallei by genome reduction and adaptation to an obligate intracellular lifestyle. Although these two bacteria cause different diseases, they share multiple virulence factors, including bacterial secretion systems, which represent key components of bacterial pathogenicity. Despite recent progress, the secretion system proteins for B. mallei and B. pseudomallei, their pathogenic mechanisms of action, and host factors are not well characterized.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 20, 2016
- Source ID
- 10.1186/s12859-016-1242-z
Entities
People
- Anders Wallqvist
- David Deshazer
- Jaques Reifman
- Kamal Kumar
- Nela Zavaljevski
- Vesna Memišević
Organizations
- Defense Threat Reduction Agency