Multistability in the epithelial-mesenchymal transition network
Abstract
The transitions between epithelial (E) and mesenchymal (M) cell phenotypes are essential in many biological processes like tissue development and cancer metastasis. Previous studies, both modeling and experimental, suggested that in addition to E and M states, the network responsible for these phenotypes exhibits intermediate phenotypes between E and M states. The number and importance of such states is subject to intense discussion in the epithelial-mesenchymal transition (EMT) community.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 24, 2020
- Source ID
- 10.1186/s12859-020-3413-1
Entities
People
- Bree Cummins
- Tomas Gedeon
- Ying Xin
Organizations
- Defense Advanced Research Projects Agency
- National Institute of General Medical Sciences
- National Science Foundation Division of Mathematical Sciences