Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes
Abstract
Genes implicated in tumorigenesis often exhibit diverse sets of genomic variants in the tumor cohorts within which they are frequently mutated. For many genes, neither the transcriptomic effects of these variants nor their relationship to one another in cancer processes have been well-characterized. We sought to identify the downstream expression effects of these mutations and to determine whether this heterogeneity at the genomic level is reflected in a corresponding heterogeneity at the transcriptomic level.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 06, 2021
- Source ID
- 10.1186/s12859-021-04147-y
Entities
People
- Emek Demir
- Hannah D. Holly
- Julia Somers
- Michal R. Grzadkowski
Organizations
- Foundation for the National Institutes of Health