Comparison study of differential abundance testing methods using two large Parkinson disease gut microbiome datasets derived from 16S amplicon sequencing
Abstract
Testing for differential abundance of microbes in disease is a common practice in microbiome studies. Numerous differential abundance (DA) testing methods exist and range from traditional statistical tests to methods designed for microbiome data. Comparison studies of DA testing methods have been performed, but none performed on microbiome datasets collected for the study of real, complex disease. Due to this, DA testing was performed here using various DA methods in two large, uniformly collected gut microbiome datasets on Parkinson disease (PD), and their results compared.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 25, 2021
- Source ID
- 10.1186/s12859-021-04193-6
Entities
People
- Zachary D Wallen
Organizations
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health
- United States Army Medical Research and Development Command