Differential contribution of p300 and CBP to regulatory element acetylation in mESCs
Abstract
The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters. Although in most cases, CBP and p300 are considered to be functionally identical, both proteins are indispensable for development and there is evidence of tissue-specific nonredundancy. However, characterization of chromatin and transcription states regulated by each protein is lacking.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 20, 2020
- Source ID
- 10.1186/s12860-020-00296-9
Entities
People
- Aishwarya Sundaresan
- Jennifer Nguyen
- Laura A Banaszynski
- Sara Martire
Organizations
- Congressionally Directed Medical Research Programs
- National Institute of General Medical Sciences
- Robert A. Welch Foundation