Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity
Abstract
Disruption of alveolar epithelial cell (AEC) differentiation is implicated in distal lung diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung adenocarcinoma that impact morbidity and mortality worldwide. Elucidating underlying disease pathogenesis requires a mechanistic molecular understanding of AEC differentiation. Previous studies have focused on changes of individual transcription factors, and to date no study has comprehensively characterized the dynamic, global epigenomic alterations that facilitate this critical differentiation process in humans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2021
- Source ID
- 10.1186/s12864-021-08152-6
Entities
People
- A. L. Ryan
- Bo Zhou
- Crystal N Marconett
- D. Mullen
- E. A. Mihalakakos
- E. Tran
- I. A. Offringa
- Jiangyi Luo
- K. D. Siegmund
- Ludi Miao
- S. K. Lynch
- T. R. Stueve
- Y. Liu
- Yaonan Wang
- Z. Borok
Organizations
- American Cancer Society
- National Cancer Institute
- National Heart, Lung, and Blood Institute
- United States Department of Defense