Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Abstract
African swine fever (ASF) is a lethal hemorrhagic disease affecting domestic pigs resulting in up to 100% mortality rates caused by the ASF virus (ASFV). The locally-adapted pigs in South-western Kenya have been reported to be resilient to disease and harsh climatic conditions and tolerate ASF; however, the mechanisms by which this tolerance is sustained remain largely unknown. We evaluated the gene expression patterns in spleen tissues of these locally-adapted pigs in response to varying infective doses of ASFV to elucidate the virus-host interaction dynamics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 19, 2022
- Source ID
- 10.1186/s12864-022-08754-8
Entities
People
- Anne W. T. Muigai
- Edward Okoth Abworo
- Eunice Magoma Machuka
- John Juma
- Joshua Oluoch Amimo
- Roger Pelle
Organizations
- Defense Threat Reduction Agency