Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing
Abstract
Early-onset renal cell carcinoma (eoRCC) is typically associated with pathogenic germline variants (PGVs) in RCC familial syndrome genes. However, most eoRCC patients lack PGVs in familial RCC genes and their genetic risk remains undefined.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 24, 2023
- Source ID
- 10.1186/s12864-023-09310-8
Entities
People
- David Y. T. Chen
- Elena V. Demidova
- Erica Golemis
- Gail L. Rosen
- Ilya G. Serebriiskii
- James Virtucio
- Mark D. Andrake
- Mary B. Daly
- Michael J. W. Hall
- Ramilia Vlasenkova
- Richard T. Pomerantz
- Roland L. Dunbrack Jr.
- Sanjeevani Arora
- Simon Kelow
- Tatiana Kent
- Tiffiney R. Hartman
Organizations
- American Cancer Society
- Kazan Federal University
- National Institutes of Health
- National Science Foundation
- United States Department of Defense