Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei
Abstract
Melioidosis is endemic in Southeast Asia and Northern Australia and is caused by the Gram-negative, facultative intracellular pathogen Burkholderia pseudomallei. Diagnosis of melioidosis is often difficult because of the protean clinical presentation of the disease, and it may mimic other diseases, such as tuberculosis. There are many different strains of B. pseudomallei that have been isolated from patients with melioidosis, but it was not clear if they could cause a similar disease in a chronic BALB/c murine model of melioidosis. Hence, we wanted to examine chronically infected mice exposed to different strains of B. pseudomallei to determine if there were differences in the host immune response to the pathogen.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 03, 2020
- Source ID
- 10.1186/s12865-020-0333-9
Entities
People
- Carl Soffler
- Christopher K Cote
- David M. Waag
- David P. Fetterer
- Jennifer L. Dankmeyer
- Jeremy J. Bearss
- Kei Amemiya
- Patricia L. Worsham
- Spencer W Stonier
- Susan L. Welkos
- Sylvia R. Treviño
- Taylor B. Chance
- Xiankun Zeng
Organizations
- Defense Threat Reduction Agency