Optical microscopy reveals the dynamic nature of B. pseudomallei morphology during β-lactam antimicrobial susceptibility testing
Abstract
In Gram-negative species, β-lactam antibiotics target penicillin binding proteins (PBPs) resulting in morphological alterations of bacterial cells. Observations of antibiotic-induced cell morphology changes can rapidly and accurately differentiate drug susceptible from resistant bacterial strains; however, resistant cells do not always remain unchanged. Burkholderia pseudomallei is a Gram-negative, biothreat pathogen and the causative agent of melioidosis, an often fatal infectious disease for humans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 16, 2020
- Source ID
- 10.1186/s12866-020-01865-w
Entities
People
- David Sue
- Heather P McLaughlin
- Julia Bugrysheva
Organizations
- Defense Threat Reduction Agency
- United States Department of Defense