Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock
Abstract
Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide prevents methemoglobin formation during storage and permits it to serve as a carbon monoxide donor. We determined whether small volume transfusion of hyperoncotic PNPH is neuroprotective in a polytrauma model of traumatic brain injury (TBI) plus hemorrhagic shock. Guinea pigs were used because, like humans, they do not synthesize their own ascorbic acid, which is important in reducing methemoglobin.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 13, 2020
- Source ID
- 10.1186/s12868-020-00571-7
Entities
People
- Bohdan Soltys
- Carleton J. C. Hsia
- Courtney L. Robertson
- Jan Simoni
- Jun Wang
- Li Ma
- Manda Saraswati
- Raymond C Koehler
- Sharon Park
- Soichiro Seno
- Suyi Cao
Organizations
- United States Army Medical Research and Development Command