Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity
Abstract
Parkinson’s disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations or agrichemicals elevate a person’s risk for PD. Here, we sought to examine the possible epigenetic changes associated with working on a plantation on Oahu, HI and/or exposure to organochlorines (OGC) in PD cases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 10, 2020
- Source ID
- 10.1186/s12868-020-00582-4
Entities
People
- Alika K. Maunakea
- G. Webster Ross
- Helen Petrovitch
- Kamal H. Masaki
- Maarit Tiirikainen
- Michael J. Corley
- Qimei He
- Rodney C. P. Go
Organizations
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging
- National Institutes of Health
- The Michael J. Fox Foundation
- Veterans Health Administration Office of Research and Development