Inhibition of adenosine A1 receptors abolished the nutritional ketosis-evoked delay in the onset of isoflurane-induced anesthesia in Wistar Albino Glaxo Rijswijk rats
Abstract
It has been demonstrated that administration of exogenous ketone supplement ketone salt (KS) and ketone ester (KE) increased blood ketone level and delayed the onset of isoflurane-induced anesthesia in different rodent models, such as Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. The modulatory effect of adenosinergic system may have a role in the ketone supplementation-evoked effects on isoflurane-generated anesthesia. Thus, we investigated whether adenosine receptor antagonists can modulate the effect of exogenous ketone supplements on the onset of akinesia induced by isoflurane.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 30, 2020
- Source ID
- 10.1186/s12871-020-0943-z
Entities
People
- Brigitta Brunner
- Csilla Ari
- Dominic P D'Agostino
- Zsolt Kovács
Organizations
- Hungarian Scientific Research Fund
- Ministry of National Development
- Office of Naval Research Global