Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction
Abstract
Metastases are the leading cause of breast cancer-related deaths. The tumor microenvironment impacts cancer progression and metastatic ability. Fibrillar collagen, a major extracellular matrix component, can be studied using the light scattering phenomenon known as second-harmonic generation (SHG). The ratio of forward- to backward-scattered SHG photons (F/B) is sensitive to collagen fiber internal structure and has been shown to be an independent prognostic indicator of metastasis-free survival time (MFS). Here we assess the effects of heterogeneity in the tumor matrix on the possible use of F/B as a prognostic tool.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2020
- Source ID
- 10.1186/s12885-020-07713-4
Entities
People
- Bradley M. Turner
- Danielle E. Desa
- Edward B Brown
- J. W. M. Martens
- Marcel Smid
- Robert L. Hill
- Robert L. Strawderman
- Wencheng Wu
Organizations
- Foundation for the National Institutes of Health
- United States Department of Defense