Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer
Abstract
Gastric cancer is a heterogeneous disease with poorly understood genetic and microenvironmental factors. Mutations in collagen genes are associated with genetic diseases that compromise tissue integrity, but their role in tumor progression has not been extensively reported. Aberrant collagen expression has been long associated with malignant tumor growth, invasion, chemoresistance, and patient outcomes. We hypothesized that somatic mutations in collagens could functionally alter the tumor extracellular matrix.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 04, 2022
- Source ID
- 10.1186/s12885-021-09136-1
Entities
People
- Alexander Brodsky
- Ayesha S. Siddique
- Dongfang Yang
- Ece D. Gamsiz Uzun
- Elizabeth Y. Wu
- Ian Y. Wong
- Jay Khurana
- Kevin S. Guo
- Murray B. Resnick
Organizations
- American Gastroenterological Association
- National Institute of General Medical Sciences