PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) – protocol for a multicenter randomized clinical trial
Abstract
Injuries and resulting stiffness around joints, especially the elbow, have huge psychological effects by reducing quality of life through interference with normal daily activities such as feeding, dressing, grooming, and reaching for objects. Over the last several years and through numerous research results, the myofibroblast-mast cell-neuropeptide axis of fibrosis had been implicated in post-traumatic joint contractures. Pre-clinical models and a pilot randomized clinical trial (RCT) demonstrated the feasibility and safety of using Ketotifen Fumarate (KF), a mast cell stabilizer to prevent elbow joint contractures. This study aims to evaluate the efficacy of KF in reducing joint contracture severity in adult participants with operately treated elbow fractures and/or dislocations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 24, 2020
- Source ID
- 10.1186/s12891-020-3139-2
Entities
People
- Alexandra Garven
- Ayoola Ademola
- Kevin A Hildebrand
- Michael J. Bosse
- Neil J. White
- Nicholas G. H. Mohtadi
- Prism S. Schneider
- Richard E. A. Walker
- Tolulope T. Sajobi
Organizations
- United States Department of Defense