Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica
Abstract
Iron is essential for bacterial survival. Bacterial siderophores are small molecules with unmatched capacity to scavenge iron from proteins and the extracellular milieu, where it mostly occurs as insoluble Fe3+. Siderophores chelate Fe3+for uptake into the cell, where it is reduced to soluble Fe2+. Siderophores are key molecules in low soluble iron conditions. The ability of bacteria to synthesize proprietary siderophores may have increased bacterial evolutionary fitness; one way that bacteria diversify siderophore structure is by incorporating different polyamine backbones while maintaining the catechol moieties.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 15, 2021
- Source ID
- 10.1186/s12915-021-00971-z
Entities
People
- Kristala L. J. Prather
- Kristina Haslinger
- Sara Cleto
- Timothy K. Lu
Organizations
- Chiron Corporation
- Defense Threat Reduction Agency
- Human Frontier Science Program
- National Institutes of Health
- Office of Naval Research