Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate
Abstract
Twenty-four-hour rhythmicity in mammalian tissues and organs is driven by local circadian oscillators, systemic factors, the central circadian pacemaker and light-dark cycles. At the physiological level, the neural and endocrine systems synchronise gene expression in peripheral tissues and organs to the 24-h-day cycle, and disruption of such regulation has been shown to lead to pathological conditions. Thus, monitoring rhythmicity in tissues/organs holds promise for circadian medicine; however, most tissues and organs are not easily accessible in humans and alternative approaches to quantify circadian rhythmicity are needed. We investigated the overlap between rhythmic transcripts in human blood and transcripts shown to be rhythmic in 64 tissues/organs of the baboon, how these rhythms are aligned with light-dark cycles and each other, and whether timing of tissue-specific rhythmicity can be predicted from a blood sample.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 09, 2022
- Source ID
- 10.1186/s12915-022-01258-7
Entities
People
- Carla S Möller-Levet
- Derk-Jan Dijk
- Emma E Laing
- Simon N. Archer
Organizations
- Air Force Office of Scientific Research
- Biotechnology and Biological Sciences Research Council