Evaluation of a serum-based antigen test for tuberculosis in HIV-exposed infants: a diagnostic accuracy study
Abstract
Non-sputum methods are urgently needed to improve tuberculosis diagnosis and treatment monitoring in children. This study evaluated the ability of a serum assay quantifying a species-specific peptide of the Mycobacterium tuberculosis CFP-10 virulence factor via nanotechnology and matrix-assisted laser desorption ionization time-of-flight mass spectrometry to diagnose tuberculosis in HIV-infected and HIV-uninfected infants.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 18, 2021
- Source ID
- 10.1186/s12916-021-01983-w
Entities
People
- Bo Ning
- Chang Liu
- Charles D. Mitchell
- Christopher J. Lyon
- Duran Bao
- Jia Fan
- Liyan Mao
- Sharon Nachman
- Soyeon Kim
- Sylvia M. Lacourse
- Tony Hu
- Ziyong Sun
Organizations
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Institute of Allergy and Infectious Diseases
- United States Department of Defense