Breast and prostate cancers harbor common somatic copy number alterations that consistently differ by race and are associated with survival
Abstract
Pan-cancer studies of somatic copy number alterations (SCNAs) have demonstrated common SCNA patterns across cancer types, but despite demonstrable differences in aggressiveness of some cancers by race, pan-cancer SCNA variation by race has not been explored. This study investigated a) racial differences in SCNAs in both breast and prostate cancer, b) the degree to which they are shared across cancers, and c) the impact of these shared, race-differentiated SCNAs on cancer survival.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 20, 2020
- Source ID
- 10.1186/s12920-020-00765-2
Entities
People
- Albert M Levin
- Benjamin A. Rybicki
- Craig G. Rogers
- Dhananjay A Chitale
- Indrani Datta
- Jia Li
- Kanika Taneja
- Lisa A. Newman
- Melissa B. Davis
- Nilesh Gupta
- Pamela L. Paris
- Ruicong She
- Sudha M. Sadasivan
- Yalei Chen
Organizations
- National Institutes of Health
- United States Department of Defense