Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain

Abstract

Few somatic mutations have been linked to breast cancer metastasis, whereas transcriptomic differences among primary tumors correlate with incidence of metastasis, especially to the lungs and brain. However, the epigenomic alterations and transcription factors (TFs) which underlie these alterations remain unclear.

Document Details

Document Type
Pub Defense Publication
Publication Date
Mar 06, 2020
Source ID
10.1186/s12920-020-0695-0

Entities

People

  • Anna Arnal-EstapĂ©
  • Celeste B. Greer
  • Don X. Nguyen
  • Jian Cao
  • Jocelyn Fang-Yi Chen
  • Qin Yan
  • Wesley L. Cai

Organizations

  • National Institutes of Health
  • National Science Foundation
  • United States Department of Defense

Tags

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Oncology