Identification of lipid biomarker from serum in patients with chronic obstructive pulmonary disease
Abstract
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States with no effective treatment. The current diagnostic method, spirometry, does not accurately reflect the severity of COPD disease status. Therefore, there is a pressing unmet medical need to develop noninvasive methods and reliable biomarkers to detect early stages of COPD. Lipids are the fundamental components of cell membranes, and dysregulation of lipids was proven to be associated with COPD. Lipidomics is a comprehensive approach to all the pathways and networks of cellular lipids in biological systems. It is widely used for disease diagnosis, biomarker identification, and pathology disorders detection relating to lipid metabolism.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 21, 2020
- Source ID
- 10.1186/s12931-020-01507-9
Entities
People
- Chi-in Vong
- Ding Liu
- Lei Li
- Maureen Meister
- Peng George Wang
- Pierre P. Massion
- Ruixie Fang
- Shiying Zhang
- Shuaishuai Wang
- Xiangming Ji
Organizations
- FAMRI
- National Cancer Institute