AMPK activation improves recovery from pneumonia-induced lung injury via reduction of er-stress and apoptosis in alveolar epithelial cells
Abstract
Bacterial pneumonia and related lung injury are among the most frequent causes of mortality in intensive care units, but also inflict serious and prolonged respiratory complications among survivors. Given that endoplasmic reticulum (ER) stress is a hallmark of sepsis-related alveolar epithelial cell (AEC) dysfunction, we tested if AMP-activated protein kinase (AMPK) affects recovery from ER stress and apoptosis of AECs during post-bacterial infection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 12, 2023
- Source ID
- 10.1186/s12931-023-02483-6
Entities
People
- Eugene Becker Jr.
- Jaroslaw W Zmijewski
- Maroof Husain
- Nathaniel Bone
- Peter Morris
- Samuel Smith
Organizations
- National Institutes of Health
- United States Department of Defense