Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers
Abstract
Quantitative interstitial abnormalities (QIA) are an automated computed tomography (CT) finding of early parenchymal lung disease, associated with worse lung function, reduced exercise capacity, increased respiratory symptoms, and death. The metabolomic perturbations associated with QIA are not well known. We sought to identify plasma metabolites associated with QIA in smokers. We also sought to identify shared and differentiating metabolomics features between QIA and emphysema, another smoking-related advanced radiographic abnormality.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 04, 2023
- Source ID
- 10.1186/s12931-023-02576-2
Entities
People
- Bina Choi
- Brian D. Hobbs
- Craig P. Hersh
- George R. Washko
- Ivan O Rosas
- Jared R. Mayers
- Jeffrey L. Curtis
- Jennifer M. Wang
- Kathleen A Stringer
- Meilan K. Han
- Raúl San José Estépar
- Rubén San José Estépar
- Russell P. Bowler
- Samuel Y. Ash
- Suneeta Godbole
- Wassim W Labaki
Organizations
- National Center for Research Resources
- National Heart, Lung, and Blood Institute
- United States Department of Defense