Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness
Abstract
The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. Here, we examined the expression of DDR1 in prostate cancer (PCa), and assessed its potential value as a prognostic marker, as a function of grade, stage and other clinicopathologic parameters.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 21, 2021
- Source ID
- 10.1186/s12935-021-02206-1
Entities
People
- Anjum Sohail
- Dongping Shi
- Hyejeong Jang
- Hyeong-reh Kim
- Marco Prunotto
- R. Daniel Bonfil
- Rafael Fridman
- Semir Vranic
- Wei Chen
Organizations
- United States Department of Defense