Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis

Abstract

Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common symptoms experienced by veterans with GWI, we examined whether the ε4 allele was associated with GWI.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jul 06, 2023
Source ID
10.1186/s12940-023-01002-w

Entities

People

  • A Keegan
  • A Nkiliza
  • D Niedospial
  • Fronefield Crawford
  • G Aldrich
  • G Bartenfelder
  • J Baraniuk
  • Kevin M. Sullivan
  • L Abdullah
  • Leon Chao
  • M Mullan
  • M. Hoffmann
  • Maxine H Krengel
  • N. Klimas

Organizations

  • Congressionally Directed Medical Research Programs
  • United States Department of Veterans Affairs

Tags

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and genetic basis of cancer.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Biotechnology