Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA
Abstract
Very few proteins encoded by the presumed non-coding RNA transcripts have been identified. Their cellular functions remain largely unknown. This study identifies the tumor-suppressor function of a novel microprotein encoded by the precursor of miR-34a. It consists of 133 amino acid residues, thereby named as miPEP133 (pri-microRNA encoded peptide 133).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 14, 2020
- Source ID
- 10.1186/s12943-020-01248-9
Entities
People
- Anirban K. Mitra
- Bo Tang
- David Patrick
- Dongin Kim
- Fangfang Bi
- Jixi Li
- Kang Liu
- Min Kang
- Rensheng Wang
- Yang Yang-Hartwich
- Ziyan Jiang
- Ziyan Zhou
Organizations
- First Affiliated Hospital of GuangXi Medical University
- Guangxi Medical University
- National Natural Science Foundation of China
- United States Department of Defense