Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade
Abstract
Accumulation of Foxp3+ regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1. However, the specific impact of these Blimp1+ Treg cells and their follicular regulatory T (TFR) cell subset on tumor and the underlying mechanisms of action are not yet well-explored.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 20, 2021
- Source ID
- 10.1186/s12943-021-01450-3
Entities
People
- Jeffrey M. Grimes
- Jianmei W Leavenworth
- Jonathan D. Leavenworth
- Lin Luo
- Michael L. Dixon
- Sadashib Ghosh
Organizations
- National Institute of Allergy and Infectious Diseases
- National Institute of Dental and Craniofacial Research
- United States Department of Defense
- University of Alabama at Birmingham School of Medicine