Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells
Abstract
Unlike autosomal tumor suppressors, X-linked tumor suppressors can be inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that targeted reactivation of the non-mutated allele from XCI offers a potential therapy for female breast cancers.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 07, 2022
- Source ID
- 10.1186/s12943-021-01472-x
Entities
People
- Chao Zhang
- Dehua Zhao
- Erica Stringer-reasor
- Lei S Qi
- Leiping Zeng
- Lizhong Wang
- Runhua Liu
- Sejong Bae
- Shuaibin Wang
- Xin Li
- Xuelian Cui
- Zhifang Xu
Organizations
- Congressionally Directed Medical Research Programs
- The Breast Cancer Research Foundation