Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest
Abstract
Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion represents a novel therapy for post-cardiac surgery organ injury. However, the effects of cardiopulmonary bypass and bovine-intestinal alkaline phosphatase infusion on tissue-level alkaline phosphatase activity/expression are unknown.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 12, 2020
- Source ID
- 10.1186/s12950-020-00256-2
Entities
People
- Amy Treece
- Danielle Soranno
- James Jaggers
- Jesse Davidson
- Justin Robison
- Ludmila Khailova
- Richard Ing
- Scott Lawson
- Suzanne Osorio Lujan
Organizations
- American Heart Association
- National Heart, Lung, and Blood Institute
- United States Department of Defense