Erythropoietin-PLGA-PEG as a local treatment to promote functional recovery and neurovascular regeneration after peripheral nerve injury
Abstract
Traumatic peripheral nerve injury (TPNI) is a major medical problem with no universally accepted pharmacologic treatment. We hypothesized that encapsulation of pro-angiogenic erythropoietin (EPO) in amphiphilic PLGA-PEG block copolymers could serve as a local controlled-release drug delivery system to enhance neurovascular regeneration after nerve injury.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 28, 2022
- Source ID
- 10.1186/s12951-022-01666-5
Entities
People
- Aijie Han
- Brandon Martinazzi
- John C Elfar
- John P. Hegarty
- Kristen M. Manto
- M. A. Hassan Talukder
- Prem Kumar Govindappa
- Zachary Koroneos
Organizations
- National Institutes of Health
- United States Department of Defense