The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells
Abstract
We have previously shown that the zinc finger transcription repressor SNAI2 (SLUG) represses tumor suppressor BRCA2-expression in non-dividing cells by binding to the E2-box upstream of the transcription start site. However, it is unclear how proliferating breast cancer (BC) cells that has higher oxidation state, overcome this repression. In this study, we provide insight into the mechanism of de-silencing of BRCA2 gene expression by PRDX5A, which is the longest member of the peroxiredoxin5 family, in proliferating breast cancer cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 27, 2020
- Source ID
- 10.1186/s12964-019-0493-5
Entities
People
- Gautam Chaudhuri
- Marshall Ellison
- Minu Chaudhuri
- Mukul Mittal
- Smita Misra
Organizations
- National Cancer Institute
- National Institute of General Medical Sciences