Induction of immunogenic cell death in radiation-resistant breast cancer stem cells by repurposing anti-alcoholism drug disulfiram
Abstract
The current successful clinical use of agents promoting robust anti-tumor immunity in cancer patients warrants noting that radiation therapy (RT) induces immunogenic cell death (ICD) of tumor cells, which can generate anti-tumor immune responses. However, breast cancer stem cells (BCSCs) are resistant to RT and RT alone usually failed to mount an anti-tumor immune response.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 05, 2020
- Source ID
- 10.1186/s12964-019-0507-3
Entities
People
- Albert B. Deleo
- Enwen Wang
- Gong Zhang
- Lile He
- Pan Hu
- Sneh M. Toprani
- Soldano Ferrone
- Ting Sun
- Wei Guo
- Wei Yang
- Xinhui Wang
- Zunwen Lin
Organizations
- Massachusetts General Hospital
- United States Department of Defense