Merlin regulates signaling events at the nexus of development and cancer
Abstract
In this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 (NF2) gene, orchestrates developmental signaling to ensure normal ontogeny, and we discuss how Merlin deficiency leads to aberrant activation of developmental pathways that enable tumor development and malignant progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 16, 2020
- Source ID
- 10.1186/s12964-020-00544-7
Entities
People
- Lalita A. Shevde
- Mateus Mota
Organizations
- National Cancer Institute
- United States Department of Defense