Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade
Abstract
The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The therapeutic effects of ABL inactivation are due in part to ABL-dependent regulation of diverse cellular processes related to the epithelial to mesenchymal transition and subsequent steps in the metastatic cascade. ABL kinases target multiple signaling pathways required for promoting one or more steps in the metastatic cascade. These findings highlight the potential utility of specific ABL kinase inhibitors as a novel treatment paradigm for patients with advanced metastatic disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 22, 2021
- Source ID
- 10.1186/s12964-021-00739-6
Entities
People
- Ann Marie Pendergast
- Ashley Colemon
- Benjamin Mayro
- Jillian Hattaway Luttman
Organizations
- Emerson Collective
- Lung Cancer Research Foundation
- National Institutes of Health
- National Science Foundation