Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis
Abstract
Clinically relevant glioma subtypes, such as the glioma-CpG island methylator phenotype (G-CIMP), have been defined by epigenetics. In this study, the role of long non-coding RNAs in association with the poor-prognosis G-CMIP-low phenotype and the good-prognosis G-CMIP-high phenotype was investigated. Functional associations of lncRNAs with mRNAs and miRNAs were examined to hypothesize influencing factors of the aggressive phenotype.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 29, 2021
- Source ID
- 10.1186/s12967-021-02844-z
Entities
People
- Chaya Brodie
- Houtan Noushmehr
- Indrani Datta
- Laila Poisson
Organizations
- National Institutes of Health
- United States Department of Defense