HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data
Abstract
Cellular compositions of solid tumor microenvironments are heterogeneous, varying across patients and tumor types. High-resolution profiling of the tumor microenvironment cell composition is crucial to understanding its biological and clinical implications. Previously, tumor microenvironment gene expression and DNA methylation-based deconvolution approaches have been shown to deconvolve major cell types. However, existing methods lack accuracy and specificity to tumor type and include limited identification of individual cell types.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 08, 2022
- Source ID
- 10.1186/s12967-022-03736-6
Entities
People
- Brock C Christensen
- Devin C Koestler
- John K Wiencke
- Karl T. Kelsey
- Lucas A. Salas
- Ze Zhang
Organizations
- American Association for Cancer Research
- Congressionally Directed Medical Research Programs
- National Institute of General Medical Sciences
- National Institutes of Health