Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors
Abstract
Low-grade serous ovarian cancer (LGSOC) is a rare disease that occurs more frequently in younger women than those with high-grade disease. The current treatment is suboptimal and a better understanding of the molecular pathogenesis of this disease is required. In this study, we compared the proteogenomic analyses of LGSOCs from short- and long-term survivors (defined as 60 months, respectively). Our goal was to identify novel mutations, proteins, and mRNA transcripts that are dysregulated in LGSOC, particularly in short-term survivors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 17, 2022
- Source ID
- 10.1186/s12967-022-03820-x
Entities
People
- Anais Malpica
- Anil K. Sood
- Brian L. Hood
- Charlotte S. Sun
- Christine Rojas
- Chun Wai Ng
- Clifton L Dalgard
- David Gershenson
- George L. Maxwell
- Jianhua Zhang
- Joseph Celestino
- Kelly A. Conrads
- Kwong K. Wong
- Matthew D. Wilkerson
- Neil T. Phippen
- Nicholas W Bateman
- P. Andrew Futreal
- R. Tyler Hillman
- Thomas P Conrads
- Tri V. Nguyen
- Yvonne T. M. Tsang
Organizations
- National Cancer Center
- National Cancer Institute
- The University of Texas MD Anderson Cancer Center
- Uniformed Services University of the Health Sciences
- United States Army