Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice
Abstract
Spinal cord injury (SCI) often results in significant and catastrophic dysfunction and disability and imposes a huge economic burden on society. This study aimed to determine whether progranulin (PGRN) plays a role in the progressive damage following SCI and evaluate the potential for development of a PGRN derivative as a new therapeutic target in SCI.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 27, 2019
- Source ID
- 10.1186/s12974-019-1630-1
Entities
People
- Aubryanna Hettinghouse
- Changhong Chen
- Chao Wang
- Chen Zhang
- Chuanju Liu
- Guodong Sun
- Jean De La Croix Ndong
- Lu Zhang
- Ronghan Liu
Organizations
- National Institutes of Health