Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair
Abstract
Excessive inflammation might activate and injure the blood-brain barrier (BBB), a common feature of many central nervous system (CNS) disorders. We previously developed an in vitro BBB injury model in which the organophosphate paraoxon (PX) affects the BBB endothelium by attenuating junctional protein expression leading to weakened barrier integrity. The objective of this study was to investigate the inflammatory cellular response at the BBB to elucidate critical pathways that might lead to effective treatment in CNS pathologies in which the BBB is compromised. We hypothesized that caspase-1, a core component of the inflammasome complex, might have important role in BBB function since accumulating evidence indicates its involvement in brain inflammation and pathophysiology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 09, 2020
- Source ID
- 10.1186/s12974-020-01927-w
Entities
People
- Dana Atrakchi
- Daniel Rand
- Fabien Gosselet
- Hila Israelov
- Itzik Cooper
- Liora Omesi
- Michal Schnaider Beeri
- Orly Ravid
- Rachel Twitto-greenberg
- Shirin Elhaik
- Sigal Liraz-zaltsman
- Yael Bresler
Organizations
- Defense Threat Reduction Agency
- Ministry of Science and Technology, Israel