Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs
Abstract
Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes in particular may contribute to post-TBI dysfunction. Moreover, microglial activation after TBI may play a role in hippocampal circuit and/or synaptic remodeling; however, the potential effects of chronic microglial changes are currently unknown. The objective of the current study was to assess neuropathological and neuroinflammatory changes in subregions of the dentate gyrus at acute to chronic time points following mild TBI using an established model of closed-head rotational acceleration induced TBI in pigs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2020
- Source ID
- 10.1186/s12974-020-1720-0
Entities
People
- D Kacy Cullen
- James P. Harris
- John A Wolf
- John E. Duda
- Kathryn L. Wofford
- Kevin D. Browne
- Michael R Grovola
- Nicholas Paleologos
- Victoria Johnson
Organizations
- Citizens United for Research in Epilepsy
- National Institute of Neurological Disorders and Stroke
- National Science Foundation
- United States Department of Defense
- United States Department of Veterans Affairs