Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis
Abstract
Follicular regulatory T (TFR) cells are essential for the regulation of germinal center (GC) response and humoral self-tolerance. Dysregulated follicular helper T (TFH) cell-GC-antibody (Ab) response secondary to dysfunctional TFR cells is the root of an array of autoimmune disorders. The contribution of TFR cells to the pathogenesis of multiple sclerosis (MS) and murine experimental autoimmune encephalomyelitis (EAE) remains largely unclear.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 19, 2021
- Source ID
- 10.1186/s12974-021-02076-4
Entities
People
- Brandon J. Pope
- Chander Raman
- Jianmei W Leavenworth
- Jonathan D. Leavenworth
- Lin Luo
- Michael L. Dixon
- William R. Meador
- Xianzhen Hu
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Alabama at Birmingham