Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner
Abstract
Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The receptor for advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate in the diseased spinal cord and RAGE has been previously implicated in the progression of ALS pathology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 15, 2021
- Source ID
- 10.1186/s12974-021-02191-2
Entities
People
- Ann Marie Schmidt
- Henry H. Ruiz
- Huilin Li
- Jiyuan Hu
- Judyta Juranek
- Laura Frye
- Michael Maclean
- Paul F. Gugger
- Raquel López-díez
- Swetha Cuddapah
Organizations
- National Institute of Neurological Disorders and Stroke
- United States Department of Defense