A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy
Abstract
There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying molecular events that cause these abnormal protein accumulations remain unclear. Here, we hypothesized that identifying the human brain proteome from serial CTE stages (CTE I-IV) would provide critical new insights into CTE pathogenesis. Brain samples from frontotemporal lobar degeneration due to microtubule associated protein tau (FTLD-MAPT) mutations were also included as a distinct tauopathy phenotype for comparison.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 25, 2021
- Source ID
- 10.1186/s13024-021-00462-3
Entities
People
- Ann C. Mckee
- Ashlyn Grace Johnson
- Chadwick M. Hales
- Duc Duong
- Eric B Dammer
- James A. Webster
- Laura Gutierrez-quiceno
- Luming Yin
- Nicholas T Seyfried
- Rhythm Shah
- Thor D Stein
- Victor E. Alvarez
Organizations
- Instituto Nacional de Ciência e Tecnologia de Adaptações da Biota Aquática da Amazônia
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Neurological Disorders and Stroke
- United States Department of Defense
- United States Department of Veterans Affairs