Heparinized chitosan stabilizes the bioactivity of BMP-2 and potentiates the osteogenic efficacy of demineralized bone matrix
Abstract
Demineralized bone matrix (DBM), an allograft bone processed to better expose osteoinductive factors such as bone morphogenetic proteins (BMPs), is increasingly used for clinical bone repair. However, more extensive use of DBM is limited by its unpredictable osteoinductivity and low bone formation capacity. Commercial DBM products often employ polymeric carriers to enhance handling properties but such carriers generally do not possess bioactive functions. Heparin is a highly sulfated polysaccharide and is shown to form a stable complex with growth factors to enhance their bioactivities. In this study, a new heparinized synthetic carrier for DBM is developed based on photocrosslinking of methacrylated glycol chitosan and heparin conjugation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 06, 2020
- Source ID
- 10.1186/s13036-020-0231-y
Entities
People
- Chen Chen
- Chung-Sung Lee
- Jiabing Fan
- Ksenia Bubukina
- Min Lee
- Soyon Kim
Organizations
- Musculoskeletal Transplant Foundation
- National Institutes of Health
- United States Department of Defense